Gastrointestinal Stromal Tumor

Researchers have identified certain genetic mutations that may contribute to the development of GIST. These genetic mutations occur in cells known as interstitial cells of Cajal (ICC), which are responsible for regulating the contractions of the digestive tract.   The mutations that cause GIST can occur spontaneously or may be inherited from a parent. Inherited mutations are rare and are typically associated with certain genetic disorders, such as neurofibromatosis type 1 (NF1) and Carney triad syndrome.   While the exact cause of GIST is not fully understood, some risk factors have been identified that may increase a person's chances of developing this rare form of cancer. These risk factors include:  

1. Age: GIST is most commonly diagnosed in people over the age of 50.
2. Gender: GIST is slightly more common in men than in women.
3. Family history: While rare, GIST can be inherited from a parent with a genetic mutation that causes the disease.
4. Certain genetic disorders: Certain genetic disorders, such as neurofibromatosis type 1 (NF1) and Carney triad syndrome, are associated with an increased risk of developing GIST.
5. Exposure to certain chemicals: Exposure to certain chemicals, such as vinyl chloride and dioxin, has been linked to an increased risk of developing GIST.

  It is important to note that having one or more of these risk factors does not necessarily mean a person will develop GIST. Many people with no known risk factors develop GIST, while others with one or more risk factors never develop the disease. If you are concerned about your risk of developing GIST, speak with a medical professional to discuss your individual risk factors and ways to reduce your risk.